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3D/4D Ultrasound

 

Benefits of Electing 3D Ultrasounds

Benefits for Electing 3D Ultrasounds

Although there is no direct medical benefit of receiving an elective 3D ultrasound, there may be many indirect benefits, as listed below. It is important to note that there has been no conclusive evidence in the medical literature to support these benefits, and in fact, the medical literature shows conflicting studies on these benefits. However, on the individual level, a pregnant woman may find any of the following benefits for herself personally.

May reduce alcohol intake

  • May encourage quitting smoking
  • May help reduce other harmful health behaviors
  • May help reduce intrapartum and post-partum depression
  • Better able to visualize the baby
  • May improve bonding between mother and child
  • May improve bonding with the father, encourage greater involvement from the father
  • Ability to determine the gender, which helps with planning for the baby and helps increase bonding through better visualization of the baby
  • Able to share pictures with family and friends
  • Historical record, pictures for the baby album
  • Makes motherhood "more real"

Controversially, Christian/Catholic non-profit organizations have employed 3D ultrasounds for young pregnant women in order to influence their decisions regarding abortion. Charitable donations or public funds help pay for the 3D ultrasound machine.

Risks of 3D ultrasounds

Generally, the risks of 3D ultrasounds mirror those of 2D ultrasounds, as it uses the same ultrasound waves at the same intensity. Unlike the comparison of CT scans to x-rays, 3D ultrasounds do not employ multiple snapshots of 2D ultrasounds but uses the 2D ultrasound images taken at various angles to construct an image. So the potential risk of 3D ultrasounds, if any, would depend on the duration of the ultrasound session rather than whether it is 2D or 3D.

The risk of ultrasounds, theoretically, would depend on the following factors:

  • Duration of ultrasound exposure
  • Intensity of ultrasound waves
  • Frequency of ultrasound sessions

Vaginal ultrasound is used for very early pregnancy, and sometimes for heavier women with more abdominal fat. This type is done trans-vaginally, using a long 'wand' (transducer) that is covered with a condom (!), lubricated, and placed inside the vagina. A male technician may ask you to insert it yourself (a female attendant should also be present in these cases, or you can request ahead of time to have a female technician instead). 

The 'wand' is then moved around your vagina to allow the technician to 'see' up into the uterus and abdomen as needed. Occasionally it needs to be pressed up on either side of your cervix firmly to 'see' the ovaries clearly, which can be a bit uncomfortable for some women, but the discomfort is usually tolerable. Some moms have likened a transvaginal ultrasound to 'having someone driving a stick shift inside.' That’s a crude but accurate description. Having a sense of humor about it makes it easier.  However, women who have sexual abuse background may want to request a female technician instead or avoid having an early ultrasound altogether, depending on their comfort levels.  

Generally speaking, the trans-vaginal ultrasound is used in the first trimester, since the uterus has not yet grown big enough to lift out of the pelvic cavity. It is very useful in getting a clearer picture to determine whether there is an ectopic pregnancy, whether the fetus is viable, if there are multiple fetuses, etc.  It is especially useful in heavyset women and perhaps in women with a retrograde uterus.  

Because the transducer is right up by the cervix and thus right next to the baby, the ultrasound waves do not have to go through the abdomen before reaching the baby, and the picture is often clearer than with an abdominal ultrasound at this point.  However, it also means the transducer is much closer to the baby than with an abdominal ultrasound, and critics worry about the safety of this.  Does the baby receive increased levels or intensity of ultrasound this way, and is this more harmful particularly because it is usually used during the first trimester?  No one knows.

The closeness of the trans-vaginal transducer (and its ability to use somewhat higher frequencies) is a particular advantage in the case of very heavy women with extensive abdominal adiposity.  Although abdominal ultrasounds definitely work on heavy women later on in pregnancy, sometimes they are not very effective earlier in pregnancy.  Thus transvaginal ultrasounds are especially common in women of size early in pregnancy. However, it is also not unusual for women of all sizes (not just heavy women) to have difficulty getting a clear abdominal ultrasound early in pregnancy, so big moms should not feel like they are the only ones having a vaginal ultrasound.  When ultrasounds are done in very early pregnancy, they are usually done transvaginally.  It is only a little later that there is a difference in ultrasound method due to size and this does not last for long.  

At some point around the end of the first trimester, most average-sized women can have an abdominal ultrasound done, but in some larger women, a transvaginal ultrasound may still need to be used for a few weeks yet in order to get a more effective picture. However, every woman is different and many larger women have reported being able to use an abdominal ultrasound at about that time too. Each case will be different and has to be decided at the time, but be aware that transvaginal ultrasounds may have to be used just a bit longer in larger women.

 

 

Benifit of 3D in obstetrical Ultrasound

 

Benefits of elective 3D ultrasounds
Although there is no direct medical benefit of receiving an elective 3D ultrasound, there may be many indirect benefits, as listed below. It is important to note that there has been no conclusive evidence in the medical literature to support these benefits, and in fact, the medical literature shows conflicting studies on these benefits. However, on the individual level, a pregnant woman may find any of the following benefits for herself personally.
May reduce alcohol intake
  • May encourage quitting smoking
  • May help reduce other harmful health behaviors
  • May help reduce intrapartum and post-partum depression
  • Better able to visualize the baby
  • May improve bonding between mother and child
  • May improve bonding with the father, encourage greater involvement from the father
  • Ability to determine the gender, which helps with planning for the baby and helps increase bonding through better visualization of the baby
  • Able to share pictures with family and friends
  • Historical record, pictures for the baby album
  • Makes motherhood "more real"
Controversially, Christian/Catholic non-profit organizations have employed 3D ultrasounds for young pregnant women in order to influence their decisions regarding abortion. Charitable donations or public funds help pay for the 3D ultrasound machine.
 
Risks of 3D ultrasounds
Generally, the risks of 3D ultrasounds mirror those of 2D ultrasounds, as it uses the same ultrasound waves at the same intensity. Unlike the comparison of CT scans to x-rays, 3D ultrasounds do not employ multiple snapshots of 2D ultrasounds but uses the 2D ultrasound images taken at various angles to construct an image. So the potential risk of 3D ultrasounds, if any, would depend on the duration of the ultrasound session rather than whether it is 2D or 3D.
The risk of ultrasounds, theoretically, would depend on the following factors:
  • Duration of ultrasound exposure
  • Intensity of ultrasound waves
  • Frequency of ultrasound sessions
 

 

Comparison of 3D and 2D Image Quality

 

How does the image quality compare with 2D ultrasound?
People generally accept that there is a slight degradation in the image quality due to the focusing of the transducer for parallel processing, but that's made up for by the fact that we're able to focus in all three dimensions rather than just two. For the actual task of detecting a tumour or lesion, because you're able to focus in all three directions, the loss of a little spatial resolution in two directions is compensated for by the 3D resolution. It's not clear whether there is any overall loss of quality - perhaps there is a little bit of a trade-off with high-speed 3D.
There's always room for improvement, however, and many, many people are working to improve ultrasound image quality. We've not yet reached an upper limit.
How is this technology being used commercially?
Most foetal imaging is done in 3D now - the technology of high-speed 3D ultrasound has almost totally overtaken everything in obstetrics. In cardiology also, probably a very high percentage of ultrasound scanners are 3D.
The ground swell of enthusiasm is not quite as great in cardiology as it is in obstetrics, but it's still growing. For example, a few years ago we developed the first 3D transoesophageal probe for cardiology and I think the first commercial version of that was released a few months ago. We have also made 3D catheters for cardiac applications - those have yet to be introduced commercially, although I think a number of companies are working on that. As time goes on, I think you'll see every 2D application supplanted by a 3D probe.
 4D GYN
 
 CCA Intima
 
 3D,4D Liver
         
 3D Female fets
 
 3D Fetal face
 
 3D Liver
         
 4 D Bladder
 
 3D Duodenum
 
 3D 4D Bladder
         
3S 4D Obs
 
 3D 26 week fetal heart
 
 4D Fetal feet and toes
       
3D Fetal spain
 
3D Stimulated Ovary
 
4D Image of 25 week fetus in Cube
   
 

 

History of 3D Ultrasound

 

3D Ultrasound & Histry
Within a couple of decades, 3D ultrasound will have totally supplanted the familiar 2D technology. That's the take of Stephen Smith, professor of biomedical engineering at Duke University (Durham, NC), who, with his colleague, Olaf von Ramm, pioneered the development of clinical 3D ultrasound scanners back in the 1980s. Since then, Smith and his research group have refined and adapted 3D ultrasound for a whole host of applications, and have market domination firmly in their sights.
Among some clinical communities, ultrasound is perceived as the poor relation when it comes to medical imaging .Its chief advantages - safety, cost-effectiveness and versatility - have led to it being used widely by non-specialists, while being shunned by many radiologists in favour of "more glamorous" modalities like CT and MRI.
But things are now looking up again for ultrasound imaging. Thanks largely to the efforts of Smith's group at Duke, ultrasound has been reincarnated with a third dimension. Being able to produce 3D images in real-time allows clinicians to observe and measure the shape and volume of patients' internal anatomy in unprecedented detail.
Since 1987, when Smith and von Ramm patented the first high-speed 3D ultrasound system, the technology has almost completely taken over the obstetrics market in the US, with cardiology applications not far behind. Michelle Jeandron spoke to Smith to get his perspective on where this evolving technology is heading.
MJ: What are the advantages of being able to do ultrasound imaging in three dimensions?
SS: For foetal imaging, the big advantage has been in looking at facial and cranial abnormalities, and being able to measure the volumes of structures in the foetus. Also, 3D imaging allows you to measure things in directions that are not available in a normal 2D image. Cardiac 3D ultrasound is still growing, but it seems that the main advantages so far are being able to measure the volume of the left ventricle - otherwise known as the stroke volume or ejection fraction - and for guiding interventional devices, such as catheters, into the heart.
I think that 3D ultrasound will also be very valuable in places where you need real-time information - i.e. in the operating room or cardiac catheterization lab, where you don't have access to CT or MRI and you certainly don't have real-time imaging. Probably within a few years, 3D ultrasound [technology] will be small enough to fit into a purse. It's not very likely that CT will ever get that portable, and neither will MRI. So when you look at the advantages of cost, real-time and portability, ultrasound will probably always have the lead.
How does the technology actually work?
All you really need to do is move the ultrasound beam back and forth in a raster pattern, say in the x and y directions, then the depth into the tissue comprises the third dimension. If you plot the echo strength as a function of x, y and z, you have a 3D image.
What's the story behind the development of 3D ultrasound technology?
Actually, 3D ultrasound has been around since the 1950s, as a curiosity or as a research tool. For a long time, however, it was too slow to be useful for clinical applications. The speed of sound in tissue is around 1500 m/s - much less than the speed of light - so it takes a long time for the ultrasound to travel into the tissue and back up to the transducer. Then you have to move the transducer to the next spot and do it again.
Our innovation was a technology called parallel processing. This means that every time you send a pulse into the body you listen for the echoes in many different directions at once, effectively speeding up the data acquisition rate. In our case, we speeded it up by a factor of 16, meaning that we were able to make images 16 times faster than usual. As a result, we're able to create real-time 3D images. That was the birth of the current technology of high-speed 3D ultrasound.

What is your team working on at the moment?
One of our current projects is looking at 3D ultrasound imaging of the brain - the cerebral vessels - which hopefully can be used as a diagnostic tool for stroke. Another project is to build a 3D transducer into the tip of several implantable devices. An example would be the so-called vena cava filter that filters out blood clots from the body, which is currently implanted via an endovascular approach using fluoroscopy. We think that we can actually integrate a 3D ultrasound probe into the implantation tip and hopefully get good images without exposing the patient to X-rays.
Basically, we're trying to look at every little device that's implanted into the body and see whether we can incorporate a 3D transducer into that device to make the implantation easier.
Looking ahead 20 or 50 years, how do you envisage 3D ultrasound being used?
I think it will have totally supplanted 2D ultrasound. Everywhere 2D is being used now there will be 3D, and it will be in portable devices that are as small as a laptop or a PDA.
The other area that we're working on is incorporating ultrasound into robotic surgery. The big breakthrough there would be if there was an autonomous robot that could do an ultrasound scan and then perform the surgery with the information that it had found using the 3D ultrasound. Looking ahead in a blue-sky way, that's what I see in the distant future.
About the author
Michelle Jeandron is science and technology reporter on medicalphysicsweb
 
 

 

 

What is 3D Ultrasound?

 

 

3D ultrasound is a medical ultrasound technique, often used during pregnancy, providing three dimensional images of the fetus. Often these images are captured rapidly and animated to produce a "4D ultrasound".

 

There are several different scanning modes in medical and obstetric ultrasound. The standard common obstetric diagnostic mode is 2D scanning. In 3D fetal scanning, however, instead of the sound waves being sent straight down and reflected back, they are sent at different angles. The returning echoes are processed by a sophisticated computer program resulting in a reconstructed three dimensional volume image of fetus's surface or internal organs, in much the same way as a CT scan machine constructs a CT scan image from multiple x-rays. 3D ultrasounds allow one to see width, height and depth of images in much the same way as 3D movies but no movement is shown. 4D ultrasounds involve the addition of movement by stringing together frames of 3D ultrasounds in quick succession.

3D ultrasound was first developed by Olaf von Ramm and Stephen Smith at Duke University in 1987

Clinical use of this technology is an area of intense research activity especially in fetal anomaly scanningbut there are also popular uses that have been shown to improve fetal-maternal bonding. 4D baby scans are similar to 3D scans except that they show fetal movement as shown in the video clip.

 

If the system is used only in the Obstetrics Application, the ultrasound energy is limited by the manufacturer below FDA limits for obstetrical ultrasound, whether scanning 2, 3 or 4 dimensionally. (The FDA limit for obstetrical ultrasound is 94 mW/cm2.) While there has been no conclusive evidence for harmful effects of 3D/4D ultrasound on a developing fetus, there still remains controversy over its use in non-medical situations, and generally, the AIUM recommends that 3D ultrasounds should be undertaken with the understanding that a risk may exist.

 

What is 4D Ultrasound?

What is 4D Ultrasound?

 

 
A 4D ultrasound machine is more than just a "babyface" ultrasound image. In fact, it's currently used in diagnosis of cardiac, obstetric, vascular, and breast applications as well as many others.
It's most common and well-known use is in fetal imaging for obstetrics. With the used 4d ultrasound machine, expectant parents can be given a clearer visualization of the life they have created at a fraction of the cost. In this day of instant gratification, what parent wants to wait nine months to meet a new member of the family? Unlike the sketchy, blurry pictures of the past, a 4d ultrasound machine can be used to significantly enhance the viewing experience while still providing real-time animation of the fetus.
The 4d ultrasound machine typically utilizes a colored image rather than black and white, which provides any viewers with a more realistic portrait of the fetus. Similarly to a conventional ultrasound, the 4d ultrasound a
 
 
  
 
 
allows a viewer to watch the baby move.

In cardiac ultrasound, 4D cardiac is used for real-time imaging of the structures of the heart to help diagnose congenital heart disease. It can provide three different axis' concurrently as well as a composite view of the heart in real-time and provides physicians with an entirely new field of view that could not be obtained.
The key difference in the two technologies (cardiac vs obstetric, vascular, or small parts) is that the cardiac 4D imaging uses a digital probe with no moving parts. This allows for a high frame rate and near true real-time imaging of the heart. To date, this is only acheivable with a cardiac sector transducer because of its small footprint (head).
We Sonotech offer both types of 4D ultrasounds. 
 

 

Basic physics of ultrasound

Basic Physic of Ultrasound and color doppler at Sonotech, Pakistan

 

Definition of Ultrasound

 

Sound with frequency greater than 20,000 cycles per second or 20kHz.  Audible sound sensed by the human ear are in the range of 20Hz to 20kHz.
Advantages:
Ultrasound can be directed as a beam.
Ultrasound obeys the laws of reflection and refraction.
Ultrasound is reflected by objects of small size.
Disadvantages:
Ultrasound propagates poorly through a gaseous medium.
The amount of ultrasound reflected depends on the acoustic mismatch.
The Four Acoustic Variables:
1.     Pressure - the amount of force over a given area.
2.     Distance - particle displacement with the wave
3.     Temperature -
4.     Density
Reflection and Propagation:
Effect of propagation through gaseous zones - poor propagation, inadequate imaging.
Effect of propagation through dense zones - nearly all of the US is reflected. Structures below dense zones are poorly imaged.

Examples of dense materials - bone, calcium, metal.

Material
Speed of Propagation
bone
4080 m/s
blood
1570 m/s
tissue
1540 m/s
fat
1450 m/s
air
330 m/s

Definition of Ultrasound and Color Doppler at Sonotech, Pakistan

Definitions:
Cycle - the combination of one rarefaction and one compression equals one cycle.
Amplitude - the maximum displacement of a particle or pressure wave.
Intensity - the amount of force or energy of sound.
Decibel (dB) - a numerical expression of the relative loudness of sound.

Wavelength - the distance between the onset of peak compression or cycle to the next.

Velocity - the velocity is the speed at which sound waves travel through a particular medium. Velocity is equal to the frequency x wavelength.
The velocity of US through human soft tissue is 1540 meters per second.

Frequency - the number of cycles per unit of time. Frequency and wavelength are inversely related. The higher the frequency the smaller the wavelength.

Acoustic Impedance - simply put, acoustic impedance is dependent on the density of the material in which sound is propagated through. The greater the impedance the more dense the material.

Reflection and Refraction

The portion of a sound that is returned from the boundary of a medium. (echo)  The angle of incidence influences the reflected and refracted waves.

 

refraction and reflection of ultrasound and color dopler at sonotech pakistan

 

 
Refraction- the change of sound direction on passing from one medium to another.

Acoustic Mismatch - the boundary between two different media where reflection and refraction occurs.

Attenuation - the decrease in amplitude and intensity as a sound wave travels through a medium.
Specular - echoes originating from relatively large, regularly shaped objects with smooth surfaces. These echoes are relatively intense and angle dependent. (i.e. IVS, valves)

Scattered
- echoes originating from relatively small, weakly reflective, irregularly shaped objects are less angle dependant and less intense. (ie. blood cells)
 

 

 

specular and scattered echoes at sonotech pakistan

 

 

Scattering: Reflection and Refraction are affected by the material being imaged.
Frequencies:

Frequencies for adult imaging - 2.0mHz to 3.0mHz.

Frequencies for pediatric imaging - 5.0mHz to 7.5mHz to 12mHz.

Effect of higher frequencies on penetration - the higher the frequency the less penetration, the lower the frequency the greater the penetration.



 

Video Lectures

 

 

Obstetric Ultrasound

Obstetric Ultrasound  at Sonotech Pakistan.

1 What are Obstetric Ultrasound Scans?

Recommended Book

 

 

 

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Obstetric Ultrasound is the use of ultrasound scans in pregnancy. Since its introduction in the late 1950’s ultrasonography has become a very useful diagnostic tool in Obstetrics.

Currently used equipments are known as, with which a continuous picture of the moving fetus can be depicted on a monitor screen. Very high frequency sound waves of between 3.5 to 7.0 megahertz (i.e. 3.5 to 7 million cycles per second) are generally used for this purpose.
They are emitted from a transducer which is placed in contact with the maternal abdomen, and is moved to "look at" (likened to a light shined from a torch) any particular content of the uterus. Repetitive arrays of ultrasound beams scan the fetus in thin slices and are reflected back onto the same transducer.
The information obtained from different reflections are recomposed back into a picture on the monitor screen (a sonogram, or ultrasonogram). Movements such as fetal heart beat and malformations in the fetus can be assessed and measurements can be made accurately on the images displayed on the screen. Such measurements form the cornerstone in the assessment of gestational age, size and growth in the fetus.
A full bladder is often required for the procedure when abdominal scanning is done in early pregnancy. There may be some discomfort from pressure on the full bladder. The conducting gel is non-staining but may feel slightly cold and wet. There is no sensation at all from the ultrasound waves.
 

 

2 Why and when is Ultrasound used in Pregnancy?

 

Ultrasound scan is currently considered to be a safe, non-invasive, accurate and cost-effective investigation in the fetus. It has progressively become an indispensible obstetric tool and plays an important role in the care of every pregnant woman.
The main use of ultrasonography are in the following areas:
 
1. Diagnosis and confirmation of early pregnancy.
The                                                                                                                      gestational sac can be visualized as early as four and a half weeks of gestation and the Yolk sac at about five weeks. The embryo can be observed and measured by about five and a half weeks. Ultrasound can also very importantly confirm the site of the pregnancy is within the cavity of the uterus.
2. Vaginal bleeding in early pregnancy.
 
 
The viability of the fetus can be documented in the presence of vaginal bleeding in early pregnancy . A visible heartbeat could be seen and detectable by pulsed Doppler ultrasound by about 6 weeks and is usually clearly depict able by 7 weeks. If this is observed, the probability of a continued pregnancy is better than 95 percent . Missed abortions and plighted ovum will usually give typical pictures of a deformed gestational sac and absence of fetal poles or heart beat.
Fetal heart rate tends to very with gestational age in the very early parts of pregnancy. Normal heart rate at 6 weeks is around 90-110 beats per minute (bpm) and at 9 weeks is 140-170 bpm. At 5-8 weeks a bradycardia (less than 90 bpm) is associated with a high risk of miscarriage.
Many women do not ovulate at around day 14, so findings after a single scan should always be interpreted with caution. The diagnosis of missed abortion is usually made by serial ultrasound scans demonstrating lack of gestational development. For example, if ultrasound scan demonstrates a 7mm embryo but cannot demonstrable a clearcut heartbeat, a missed abortion may be diagnosed. In such cases, it is reasonable to repeat the ultrasound scan in 7-10 days to avoid any error.

 

diagnosed. In such cases, it is reasonable to repeat the ultrasound scan in 7-10 days to avoid any error. The timing of a positive pregnancy test may also be helpful in this regard to assess the possible dates of conception. A positive pregnancy test 3 weeks previously for example, would indicate a gestational age of at least 7 weeks. Such information would be useful against the interpretation of the scans. 
In the presence of first trimester bleeding, ultrasonography is also indispensible in the early diagnosis of ectopic pregnancies and moral pregnancies.                                                                                                 

   

 

 

 

3. Determination of gestational age and assessment of fetal size.

Fetal body measurements reflect the gestational age of the fetus. This is particularly true in early gestation. In patients with uncertain last menstrual periods, such measurements must be made as early as possible in pregnancy to arrive at a correct dating for the patient. See. In the latter part of pregnancy measuring body parameters will allow assessment of the  size and growth of fetus and will greatly assist in the diagnosis and management of intrauterine growth retardation ( IUGR ).
A structure that develops in the uterus early in pregnancy, enclosing the developing baby and amniotic fluid. In an ultrasound, the gestational sac should be visible by five weeks of pregnancy. Measurement of the gestational sac diameter (GS) should increase by about 1 mm per day in early pregnancy.
This measurement can be made between 7 to 13 weeks and gives very accurate estimation of the gestational age. Dating with the CRL can be within 3-4 days of the last menstrual period. (An important point to note is that when the due date has been set by an accurately measured CRL, it should not be changed by a subsequent scan. For example, if another scan done 6 or 8 weeks later says that one should have a new due date which is further away, one should not normally change the date but should rather interpret the finding as that the baby is not growing at the expected rate.

 

The diameter between the 2 sides of the head. This is measured after 13 weeks. It increases from about 2.4 cm at 13 weeks to about 9.5 cm at term. Different babies of the same weight can have different head size, therefore dating in the later part of pregnancy is generally considered unreliable. (Chart and further comments) Dating using the BPD should be done as early as is feasible.

 

Measures the longest bone in the body and reflects the longitudinal growth of the fetus. Its usefulness is similar to the BPD. It increases from about 1.5 cm at 14 weeks to about 7.8 cm at term. (Chart and further comments) Similar to the BPD, dating using the FL should be done as early as is feasible.
The single most important measurement to make in late pregnancy. It reflects more of fetal size and weight rather than age. Serial measurements are useful in monitoring growth of the fetus. (Chart and further comments) AC measurements should not be used for dating a fetus.

 

Fetal age conception guideline

 
 
The development of a baby is quite an intricate journey. From the moment that the egg and sperm meet, a baby is beginning the developmental process. This early part of development lays the foundation for a healthy pregnancy and the birth of a healthy baby. Unfortunately, because these early weeks involve such a complex process, things can go wrong and ultimately end in a pregnancy loss. If a possible complication in early pregnancy is suspected, your health care provider will use a combination of blood tests and ultrasound tests to make a clear diagnosis. A blood test can be used to monitor hCG levels and progesterone levels. Ultrasounds can be used to visually see what development is taking place in the uterus and to measure the progress.
It is common to have many questions about what this early development truly involves and what is to be expected. We have gathered information from different sources in order to provide the best guidelines of what normal early fetal development looks like. However, just as every woman is different, every pregnancy develops differently. This information should be used as a general guide for healthy pregnancy development, although development may vary due to the mother’s health or a miscalculation of ovulation. Gestational age is the age of the pregnancy from the last normal menstrual period (LMP), and fetal age is the actual age of the growing baby. Most references to pregnancy are usually in gestational age rather than fetal age development, but we have included both so that it is clear what stage development is at.
Week 1 & 2 Gestational Age - (Conception)

Page 2 - Fetalage Conception Guidline

At this stage, the menstrual period has just ended and your body is getting ready for ovulation. For most women, ovulation takes place about 11 - 21 days from the first day of the last menstrual period. During intercourse, several hundred million sperm are released in the vagina. Sperm will travel through the cervix and into the fallopian tubes. When conception takes place, the sperm will penetrate an egg and create a single set of 46 chromosomes called a zygote - the basis for a new human being. The fertilized egg, called a morula, spends a couple of days traveling through the fallopian tube toward the uterus and dividing into cells (this dividing process is where many chromosomal abnormalities occur). The morula becomes a blastocyst and will eventually end up in the uterus. Anywhere from day 6 - 12 after conception, the blastocyst will imbed into the uterine lining and begin the embryonic stage.
Weeks 3-4 - Gestational Age (Fetal Age 2 weeks)
Development
The earliest change that can be seen through a vaginal ultrasound at this time will be the “decidual reaction” which is the thickening of the endometrium. The endometrium lining thickens as the blastocyst burrows into it. This cannot always be detected by ultrasound—sometimes it may take a special eye or very good equipment to see this “reaction” in the endometrium lining.
*A key fact to remember when using ultrasounds is that a transvaginal ultrasound can detect development in the uterus about a week earlier than a transabdominal ultrasound.
Hormones

 

Page 3 - Fetalage Conception Guidline

hCG: Once implantation occurs, the pregnancy hormone Human Chorionic Gonadotropin (hCG) will develop and begin to rise. This hormone will signal that you are pregnant on a pregnancy test. hCG can be detected through two different types of blood tests or through a urine test. A quantitative blood test measures the exact amount of hCG in the blood, and a qualitative hCG blood test gives a simple yes or no answer to whether you are pregnant or not.
Doctors will often use the quantitative test if they are closely monitoring the development of a pregnancy. After implantation occurs, the hormone will begin to rise and should increase every 48-72 hours for the next several weeks.
Progesterone: The follicle from which the egg was released is called the corpus luteum. It will release progesterone that helps thicken and prepare the uterine lining for implantation. The corpus luteum will produce progesterone for about 12-16 days (the luteal phase of your cycle.) When the egg is fertilized, the corpus luteum will continue to produce progesterone for the developing pregnancy until the placenta takes over around week 10. Progesterone is the hormone that helps maintain the pregnancy until birth. Sometimes, the failure of the corpus luteum to adequately support the pregnancy with progesterone can result in an early pregnancy loss. Progesterone inhibits immune responses, decreases prostaglandins, and prevents the onset of uterine contractions.
Week 5 - Gestational Age (Fetal age 3 weeks)
Development
The gestational sac is often the first thing that most transvaginal ultrasounds can detect at about 5 weeks. This is seen before a recognizable embryo can be seen. Within this week, at about week 5 ½ to the beginning of the 6th week, a yolk sac can be seen inside the gestational sac. The yolk sac will be the earliest source of nutrients for the developing fetus.
Hormones

Page 4 - Fetalage Conception Guidline

Human chorionic gonadotropin (hCG) levels can have quite a bit of variance at this point. Anything from 18 - 7,340 mIU/ml is considered normal at 5 weeks. Once the levels have reached at least 2000, some type of development is expected to be seen in the uterus using high resolution vaginal ultrasound. If using a transabdominal ultrasound, some type of development should be seen when the hCG level has reached 3600 mIU/ml. Although development may be seen earlier, these levels provide a guide of when something is expected to be seen.
Progesterone levels also can have quite a variance at this stage of pregnancy. They can range from 9-47ng/ml in the first trimester, with an average of 12-20ng/ml in the first 5-6 weeks of pregnancy.
With both hCG levels and progesterone levels, it is not the single value that can predict a healthy pregnancy outcome. It is more important to evaluate two different values to see if the numbers are increasing. Levels of hCG should be increasing by at least 60 % every 2-3 days, but ideally doubling every 48-72 hours. Progesterone levels rise much differently than hCG levels, with an average of 1-3ng/ml every couple days until they reach their peak for that trimester. In situations when there is a concern of an ectopic pregnancy or miscarriage, hCG levels will often start out normal, but will not show a significant increase or will stop rising all together, and progesterone levels will be low from the beginning.
Week 6 - Gestational Age (Fetal age 4 weeks)
5 ½ to 6 ½ weeks is usually a very good time to detect either a fetal pole or even a fetal heart beat by vaginal ultrasound. The fetal pole is the first visible sign of a developing embryo. This pole structure actually has some curve to it with the embryo’s head at one end and what looks like a tail at the other end. The fetal pole now allows for crown to rump measurements (CRL) to be taken, so that pregnancy dating can be a bit more accurate. The fetal pole may be seen at a crown-rump length (CRL) of 2-4mm, and the heartbeat may be seen as a regular flutter when the CRL has reached 5mm.
If a vaginal ultrasound is done and no fetal pole or cardiac activity is seen, another ultrasound scan should be done in 3-7 days. Due to the fact that pregnancy dating can be wrong, it would be much too early at this point to make a clear diagnosis on the outcome of the pregnancy.
Week 7 - Gestational Age (Fetal Age 5 weeks)

 

Page 5 - Fetalage Conception Guidline

Generally from 6 ½ -7 weeks is the time when a heartbeat can be detected and viability can be assessed. A normal heartbeat at 6-7 weeks would be 90-110 beats per minute. The presence of an embryonic heartbeat is an assuring sign of the health of the pregnancy. Once a heartbeat is detected, the chance of the pregnancy continuing ranges from 70-90% dependent on what type of ultrasound is used. If the embryo is less than 5mm CRL, it is possible for it to be healthy without showing a heartbeat, though a follow up scan in 5-7 days should show cardiac activity.
If your doctor is concerned about miscarriage, blighted ovum, or ectopic pregnancy, the gestational sac and fetal pole (if visible) will be measured to determine what type of development should be seen. The guideline is that if the gestational sac measures >16-18mm with no fetal pole or the fetal pole measures 5mm with no heartbeat (by vaginal ultrasound), then a diagnosis of miscarriage or blighted ovum is made. If the fetal pole is too small to take an accurate measurement, then a repeat scan should be done in 3-5 days. If there is absence of a fetal pole, then further testing should be done to rule out the possibility of an ectopic pregnancy.
Week 8 & 9 - Gestational Age (Fetal Age 6-7 weeks)
By this point in the pregnancy, everything that is present in an adult human is present in the developing embryo. The embryo has reached the end of the embryonic stage and now enters the fetal stage. A strong fetal heartbeat should be detectable by ultrasound, with a heartbeat of 140-170 bpm by the 9th week. If a strong heartbeat is not detected at this point, another ultrasound scan may be done to verify the viability of the fetus. If a pregnancy has been diagnosed as non-viable, most physicians will give the choice of waiting to see if the body will miscarry naturally (pending no other health issues) or to have a Dilation & Curettage (D&C) procedure. About 50% of women do not undergo a D&C procedure when an early pregnancy loss has occurred.
Hormones

Page 6 - Fetalage Conception Guidline

The hCG levels will peak at about 8-12 weeks of pregnancy and then will decline, remaining at lower levels throughout the remainder of the pregnancy. If the levels are questionable, an ultrasound scan should be used to diagnose the pregnancy outcome. Ultrasound findings are much more accurate at diagnosing pregnancy viability after 5-6 weeks gestation than hCG levels are.

Guideline to hCG levels during pregnancy:
hCG levels in weeks from LMP (gestational age)* :
·         3 weeks LMP: 5 - 50 mIU/ml
·         4 weeks LMP: 5 - 426 mIU/ml
·         5 weeks LMP: 18 - 7,340 mIU/ml
·         6 weeks LMP: 1,080 - 56,500 mIU/ml
·         7 - 8 weeks LMP: 7,650 - 229,000 mIU/ml
·         9 - 12 weeks LMP: 25,700 - 288,000 mIU/ml
·         13 - 16 weeks LMP: 13,300 - 254,000 mIU/ml
·         17 - 24 weeks LMP: 4,060 - 165,400 mIU/ml
·         25 - 40 weeks LMP: 3,640 - 117,000 mIU/ml
·         Non-pregnant females: <5.0 mIU/ml
·         Postmenopausal: <9.5 mIU/ml
Guideline to Progesterone levels during pregnancy:
• 1-28 ng/ml Mid Luteal Phase (Average is over 10 for un-medicated cycles and over 15 with medication use)
• 9-47 ng/ml First trimester
• 17-146 ng/ml Second Trimester
• 49-300 ng/ml Third Trimester
*There are many averages for progesterone levels. These charts are a very broad guideline—speak with your health care professional for more specific guidelines for you.
**Remember - These numbers are just a GUIDELINE -- every woman’s hormone level can rise differently. It is not necessarily the level that matters but rather the change in the level.

When you should check Fetal Anomalies?

 

An ultrasound is done in most pregnancies around the mid part of a pregnancy. This is sonographical study is known as the fetal anatomy survey or the fetal anomaly screen. It is recommended to do a scan on 18-22 weeks of pregnanancy.
 
The way this scan is done is that woman will have a full bladder before the start of the exam. Sonologist  will do ultrasound . woman pregnant belly will have a special gel placed on it to help enhance the picture from the sound waves of the ultrasound. you, or in some cases the physician, will use the ultrasound transducer wand and move it over her abdomen.
 
An ultrasound is done in most pregnancies around the mid part of a pregnancy. This is sonographical study is known as the fetal anatomy survey or the fetal anomaly screen. It is recommended to do a scan on 18-22 weeks of pregnanancy. The way this scan is done is that woman will have a full bladder before the start of the exam. Sonologist  will do ultrasound . woman pregnant belly will have a special gel placed on it to help enhance the picture from the sound waves of the ultrasound. you, or in some cases the physician, will use the ultrasound transducer wand and move it over her abdomen.
Ultrasonologist determine things about  baby and  pregnancy. You need to look on the  size of  baby in comparison to others babies of the same gestational age or they may look at placenta.
 

 

 
We often talk about how the first thing we'll do after our baby is born is to count fingers and toes. Now ultrasound technology can enable use to count fingers and toes prior to birth. Though being able to count each finger and toe can depend on how cooperative baby is being during the ultrasound exam.

 

 

It is more likely that sonologistwill be able to see bigger areas like  baby's limbs - arms and legs. Ultrasound technician will measure  baby's thigh bone (femur), the tibia and fibula. These will also help calculate how well  baby is growing for his or her gestational age.In addition to look at the legs, Sonologist should also  measure parts of  baby's arms. The bones of the arms (radius, ulna) are measured when possible.
 

 

 

BPD The diameter between the 2 sides of the head. This is measured after 13 weeks. It increases from about 2.4 cm at 13 weeks to about 9.5 cm at term. Different babies of the same weight can have different head size, therefore dating in the later part of pregnancy is generally considered unreliable. (Chart and further comments) Dating using the BPD should be done as early as is feasible.
 

BPD 

The single most important measurement to make in late pregnancy. It reflects more of fetal size and weight rather than age. Serial measurements are useful in monitoring growth of the fetus. (Chart and further comments) AC measurements should not be used for dating a fetus.

Abdominal Circumference
The Femur length  Measures the longest bone in the body and reflects the longitudinal growth of the fetus. Its usefulness is similar to the BPD. It increases from about 1.5 cm at 14 weeks to about 7.8 cm at term. (Chart and further comments) Similar to the BPD, dating using the FL should be done as early as is feasible.
 

28 Week

Ultrasonography has become indispensible in the localization of the site of the placenta and determining its lower edges, thus making a diagnosis or an exclusion of placenta previa. Other placental abnormalities in conditions such as diabetes, fetal hydrops, Rh isoimmunization and severe intrauterine growth retardation can also be assessed.

Placenta

Transvaginal Scan With specially designed probes, ultrasound scanning can be done with the probe placed in the vagina of the patient. This method usually provides better images (and therefore more information) in patients who are obese and/ or in the early stages of pregnancy. The better images are the result of the scanhead's closer proximity to the uterus and the higher frequency used in the transducer array resulting in higher resolving power. Fetal cardiac pulsation can be clearly observed as early as 6 weeks of gestation.

 

 

TVS Scan 6 week

The sex of the baby can usually be determined by ultrasound at any time after 16 weeks, often at the dating scan around 20 weeks into the pregnancy depending upon the quality of the sonographic machine and skill of the operator. This is also the best time to have an ultrasound done as most infants are the same size at this stage of development. Depending on the skill of the sonographer, ultrasound may suffer from a high rate of false negatives and false positives. This means care has to be taken in interpreting the accuracy of the scan.

 

 

Boy

 

 

Ultrasound Transducers Care Safety and Cleaning

 

 

 

 

Recommended by GE Medical healthcare
Transducer Care & Safety Guidelines
 
·         Handle all transducers with care.
·         Prevent damage to transducers by placing them in their holder, carrying case or storage drawer when not in use.
·         Do not drop or subject transducer to any type of mechanical shock. Impact may compromise probe operation, safety features or result in sharp edges that could damage the protective sheath and/ or injure sensitive tissue.
·         Inspect transducer lens, cable & housing before each exam.
·         Do not use damaged transducers. Injury to the operator or patient may occur if cracks, cuts, sharp edges or exposed wiring exist. Cleaning and/ or gel solutions may leak into the transducer resulting in electrical shock. Discontinue use and notify the GE Service representative.
·         Avoid unnecessary stress or bending to cable.
·         Do not twist, kink or pinch cable. Excessive bending or stress on cable may result in damage to its insulating properties causing shock to the patient or operator.
·         Strictly follow the immersion table provided in this guide when cleaning & disinfecting probes.
·         Do not soak transducer longer than recommended by germicide manufacturer.
·         Do not immerse transducer connector in germicide.
·         Use only compatible gels and germicides and strictly follow the manufacturers instructions when applying, cleaning & disinfecting transducers.
·         Do not use non-recommended coupling gels that contain lotions, mineral oil, olive oil, lanolin, polyethylene glycol, dimethylsilicone, methyl or ethyl parabens.
·         Do not clean transducers with non-recommended germicides that contain methanol, ethanol, bleach or alcohol.
·         Do not steam, heat autoclave or use ethylene oxide (EO) gas processes on general surface or TE/TV/TR transducers.
 
Transducer Cleaning Guide
Note: Prevent disease transmission by properly cleaning & disinfecting transducer surfaces (between patients) that come in contact with body tissue.
·         Refer to the APIC Guidelines for Selection & Use of Disinfectants.
·         Always use sterile, legally marketed transducer sheaths for intra-cavitary, intra-operative and biopsy procedures.
·         GE does not substantiate the claims of infection control capabilities of recommended germicides.
·         Strictly follow the germicide manufacturers instructions for duration of contact time.
·         Failure to do so may result in ineffective decontamination, as well as, severe lens damage & transducer failure not covered under the GE product warranty.

Cleaning - All Transducers
·         Disconnect transducer from ultrasound console and rinse probe with a warm nonabrasive soap & water solution.
·         Meticulously scrub transducer as needed with a soft brush, sponge or gauze pad to remove all gel and bio-residues.
·         Air dry or dry with soft cloth or gauze pad.
Low Level Disinfecting: General Surface Transducers
After cleaning transducer: Spray, wipe or immerse transducer in a disinfectant (see Table) as directed by the germicide manufacturer. Thoroughly rinse with sterile water and pat dry with a soft sponge, cloth or gauze pad.
High Level Disinfecting: TE/TV/TR Transducers
After cleaning transducer: Immerse transducers that come in contact with mucous membranes, blood or other body fluids in a GE-compatible high level disinfectant
Strictly follow the germicide manufacturers instructions. Thoroughly rinse with sterile water and pat dry with a soft sponge, cloth or gauze pad.
 
Note: Use quality gel to protect your probe .
 

Probe Protection

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